Laboratory testing was notable for elevated ESR at 83 mm/hr and CRP at 68 mg/dL. Testing for C. difficile toxin and stool cultures for bacteria, viruses, and parasites were negative.
She was given IV methylprednisolone 60 mg/day to induce remission.
Which of the following, if present on hospital day three, would predict corticosteroid failure (may be more than one)?
Prior treatment with corticosteroids
Prior treatment with steroids has not been shown to predict IV corticoid failure during acute severe ulcerative colitis
Biologic therapy prior to admission
Biologic therapy prior to admission has not been shown to predict IV corticoid failure during acute severe ulcerative colitis
Normal serum Albumin
Hypoalbuminemia at day 3 has been shown to be predictive of steroid failure and is a component to the Ho Index
Persistent Frequent Bowel Movements
The Travis score uses either >8 BM/day or 3-8 BM/day with CRP>45 mg/dL as predictors of failure of steroid therapy.
CRP > 45mg/dL
The Travis Score uses 3-8 BM/day with CRP>45 mg/dL as predictors of failure of steroid therapy
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